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翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Antibiotic acyldepsipeptides ： ウィキペディア英語版 Antibiotic acyldepsipeptides Acyl depsipeptides (ADEPs) are antibiotics that destroy intracellular proteins, by deregulating the ClpP protease. == Background == ADEPs are effective against gram positive bacteria, including pathogens.〔 Upon binding, ADEPs prevent the assembly of the ClpP-ATPase complex. Clp-family proteins are ATP-dependent proteases which play a crucial role in the cell function by degrading misfolded proteins. ClpP is a monomer on its own but oligomerizes into tetradecamers when bound to ATPases. It needs an ATPase to identify, unfold, and transfer targeted big proteins into its proteolytic channel.〔 In fact, ClpP on its own can only degrade peptides that are up to six amino long.〔 ADEP binding induces ClpP proteolytic activation that leads to the proteins degradation in the cell, especially nascent proteins and the Ftsz protein which is an important protein in cell division.〔〔 This potentially leads to cell death and is the reason why ADEP is a promising technique for drug development. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Antibiotic acyldepsipeptides」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.